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1.
Proc Natl Acad Sci U S A ; 121(10): e2317832121, 2024 Mar 05.
Article in English | MEDLINE | ID: mdl-38412136

ABSTRACT

Non-Newtonian fluids can be used for the protection of flexible laminates. Understanding the coupling between the flow of the protecting fluid and the deformation of the protected solids is necessary in order to optimize this functionality. We present a scaling analysis of the problem based on a single coupling variable, the effective width of a squeeze flow between flat rigid plates, and predict that impact protection for laminates is optimized by using shear-thinning, and not shear-thickening, fluids. The prediction is verified experimentally by measuring the velocity and pressure in impact experiments. Our scaling analysis should be generically applicable for non-Newtonian fluid-solid interactions in diverse applications.

2.
Biomicrofluidics ; 8(4): 046505, 2014 Jul.
Article in English | MEDLINE | ID: mdl-25379110

ABSTRACT

In this article, we present a simple, rapid prototyped polystyrene-based microfluidic device with three-dimensional (3D) interconnected microporous walls for long term perfusion cell culture. Patterned 3D interconnected microporous structures were created by a chemical treatment together with a protective mask and the native hydrophobic nature of the microporous structures were selectively made hydrophilic using oxygen plasma treatment together with a protective mask. Using this polystyrene-based cell culture microfluidic device, we successfully demonstrated the support of four days perfusion cell culture of hepatocytes (C3A cells).

3.
Lab Chip ; 11(19): 3249-55, 2011 Oct 07.
Article in English | MEDLINE | ID: mdl-21833418

ABSTRACT

This article presents a simple, low-cost method of fabrication and the applications of flexible polystyrene microfluidic devices with three-dimensional (3D) interconnected microporous walls based on treatment using a solvent/non-solvent mixture at room temperature. The complete fabrication process from device design concept to working device can be completed in less than an hour in a regular laboratory setting, without the need for expensive equipment. Microfluidic devices were used to demonstrate gas generation and absorption reactions by acidifying water with carbon dioxide (CO(2)) gas. By selectively treating the microporous structures with oxygen plasma, acidification of water by acetic acid (distilled white vinegar) perfusion was also demonstrated with the same device design.


Subject(s)
Gases/chemistry , Microfluidic Analytical Techniques/methods , Absorption , Acetic Acid/chemistry , Carbon Dioxide/chemistry , Hydrogen-Ion Concentration , Microfluidic Analytical Techniques/instrumentation , Polystyrenes/chemistry , Porosity , Temperature , Water/chemistry
4.
Appl Opt ; 42(15): 2683-8, 2003 May 20.
Article in English | MEDLINE | ID: mdl-12777003

ABSTRACT

We describe the performance of a fiber-optic power-limiting component. The passive device is dynamically responsive to the input signal and has been shown to attenuate continuous-wave power with a dynamic range of up to 9 dB at 150 mW of input power at 1550 nm. The limiting threshold is approximately 30 mW from 1530 to 1565 nm and less than 10 mW at 1430 nm. The device is activated by a photothermal defocusing mechanism in an optical polymer fixed between two expanded core fibers that collimate light through the material. The magitude and threshold of the limiting response is dependent on the absorption properties of the polymer and the size of the gap between the two fiber endfaces. Simple model calculations have been made to predict the limiting response, and they agree reasonably well with the performance of the actual device.

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